Effects manufacturing method on surface mineralization of bioactive glasses

  • Author / Creator
    Pirayesh, Hamidreza
  • Amorphous bioactive glass powders are used as bone-filling materials in many medical applications. Bioactivity is achieved through ion exchange with bodily fluids, leading to surface apatite mineral formation – a necessity for tissue development. Traditional fabrication is by melt-casting and grinding, however sol-gel synthesis is another method which directly produces powders with higher
    specific surface area and potential for increased ion exchange rates. In this study sol-gel derived powders were manufactured and compared with melt-cast powders to determine the effects of crystallinity, composition, and specific surface area on apatite formation. Powders were immersed in simulated body fluid as a function of time and the evolution of apatite minerals was characterized.
    Apatite formation was most significantly affected by powder composition, followed by specific surface area; merely having sodium in the powder was more influential than altering the surface area and/or atomic structure, yet high specific surface area was found to enhance reactions on crystalline powders.

  • Subjects / Keywords
  • Graduation date
    Fall 2010
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.