Gene-Environmental Interaction Assessment in Genome Wide Association Study

• Author / Creator

  Liu, Wei

• This thesis aimed to investigate congestive heart failure (CHF) associated with anthracycline exposures among the childhood cancer survivors, trying to identify differential anthracycline effects by genotype of certain genes. We had 130 childhood cancer survivors who developed CHF as cases and 269 individually-matched controls. We assessed each single nucleotide polymorphism’s (SNP) interaction with anthracycline dose on the case-control status of CHF. Besides the single SNP analysis, we developed a method that considered SNPs from the same gene as a set and assessed the set’s effect on anthracycline toxicity by extending a gene-set analysis method developed previously for gene expression studies. Some SNPs had interactions with anthracycline exposure on the development of CHF. Moreover, there was stronger evidence from the SNP-set analysis indicated that the interaction between certain sets of SNPs (genes) and anthracycline exist.

• Subjects / Keywords

  • Congestive heart failure--Genetic aspects--Case studies
  • Cancer in children--Genetic aspects--Case studies
  • Cancer--Genetic aspects--Case studies
  • Cancer--Patients--Rehabilitation
  • Cancer--Environmental aspects
  • Anthracyclines--Synthesis--Genetic aspects
  • Heart failure in children--Genetic aspects--Case studies

• Graduation date

  Fall 2011

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3JT6C

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.