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Therapies for preeclampsia and fetal growth restriction: restoration of uterine blood flow tested in mouse models Open Access


Other title
Preeclampsia, Fetal growth restriction, Therapies
Type of item
Degree grantor
University of Alberta
Author or creator
Poudel, Rajan
Supervisor and department
Dr Philip N Baker, Department of Medicine
Dr Sandra T Davidge, Departments of Obstetrics and Gynaecology and Physiology
Examining committee member and department
Dr Evangelos Michelakis, Department of Medicine
Dr Nadia Jahroudi, Department of Medicine
Department of Physiology

Date accepted
Graduation date
Master of Science
Degree level
Preeclampsia (PE) and fetal growth restriction (FGR) complicate over 10% of human pregnancies and contribute significantly to fetal and maternal morbidity and mortality. Although the causes of PE and FGR are not well understood, they are known to be associated with impaired uterine artery blood flow. Endothelial nitric oxide synthase knockout mice (eNOS-/-) and catechol-O-methyltransferase knockout mice (COMT-/-) exhibit many signs of PE during pregnancy and deliver growth-restricted pups. We tested the ability of two potential treatments; resveratrol and 2-methoxyestradiol (2-ME) to increase uteroplacental blood flow and therefore ameliorate signs of PE and rescue FGR in relevant mouse models. 2-ME administration led to normalization of umbilical artery blood flow velocity and proteinuria in COMT-/- mice. Resveratrol supplementation increased uterine artery blood flow velocity and pup weight in COMT-/- but not in eNOS-/- mice. Our results indicate that resveratrol and 2-ME may have therapeutic potential in cases of PE and FGR.
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