ERA

Download the full-sized PDF of A Serological Diagnosis of Celiac Disease: A Pilot Study Toward Changing Local PracticeDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3W97P

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

A Serological Diagnosis of Celiac Disease: A Pilot Study Toward Changing Local Practice Open Access

Descriptions

Other title
Subject/Keyword
pediatrics
Celiac Disease
serological diagnosis
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Rajani, Seema
Supervisor and department
Turner, Justine (Paediatrics)
Persad, Rabin (Paediatrics)
Examining committee member and department
Bamforth, Fiona (Medical Genetics)
Huynh, Hien (Paediatrics)
Rempel, Gwen (Nursing)
Persad, Sujata (Paediatrics)
Department
Medical Sciences-Paediatrics
Specialization

Date accepted
2015-01-28T10:49:30Z
Graduation date
2015-06
Degree
Master of Science
Degree level
Master's
Abstract
Introduction: Celiac disease (CD) is the most common autoimmune disorder of the gastrointestinal tract. In 2012, the European Society for Pediatric Gastroenterology, Hepatology and Nutrition changed their guidelines for CD diagnosis to include a serological diagnosis for certain patients instead of an endoscopy followed by biopsy. The purpose of this study is: (1) to apply a modified serological protocol in a prospective manner, (2) to evaluate the use of non-invasive monitoring of mucosal damage and (3) conduct qualitative interviews to determine if diagnostic strategy affects outcome, on a gluten free diet (GFD). Methods: Pediatric patients were given the option of a serological diagnosis if their anti-tissue transglutaminase (aTTG) level was ≥200 U/mL. Those that had an aTTG <200 U/mL were diagnosed by biopsy. In both groups, intestinal permeability and inflammation were assessed using standard non-invasive measurements of sugar probes in urine and fecal calprotectin. Parental phone interviews were also conducted in a subset of each diagnostic group. Conclusions: Our enrollment rate and parent response in interviews demonstrate that, in our local center, parents and patients welcome a non-invasive diagnostic strategy. There were no adverse affects in regards to symptom improvement or adherence to the GFD in those diagnosed by serology. After 12 months of treatment on a gluten-free diet, all CD patients showed recovery in intestinal permeability and inflammation through non-invasive measurements.
Language
English
DOI
doi:10.7939/R3W97P
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2015-06-15T07:05:56.427+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (PDF/A)
Mime type: application/pdf
File size: 2278840
Last modified: 2015:10:21 00:54:59-06:00
Filename: Rajani_Seema_201501_MSc.pdf
Original checksum: 9e0789d26c9360ae128944cdace0e9de
Activity of users you follow
User Activity Date