Cumulative Total Incidence for Estimating the Burden of Recurrent Events and Risk vs. Rate Concepts and Regression Models in Epidemiology

• Author / Creator

  Dong, Huiru

• In the first part of this thesis, a straightforward intuitive method for descriptive survival analysis, termed “cumulative total incidence”, is proposed to measure the total burden of recurrent events in a population by a given time. Using data from the Childhood Cancer Survivor Study, demonstrate the utility of this method contrasting this method to cumulative incidence. In the second part of this thesis, the concepts of risk and rate, and their relationship are discussed in the framework of survival analysis. Regression approaches for estimating the association between factors on event risk and event rate are discussed. Using data from the Childhood Cancer Survivor Study on two competing outcomes, we further demonstrate how competing-risk event affects the estimated association of covariates of interest with event risk and rate.

• Subjects / Keywords

  • Competing risks
  • Recurrent events
  • Survival analysis
  • Risk vs. rate
  • Cumulative total incidence

• Graduation date

  Fall 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R33F4KZ9Q

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.