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Cumulative Total Incidence for Estimating the Burden of Recurrent Events and Risk vs. Rate Concepts and Regression Models in Epidemiology Open Access


Other title
risk vs. rate
competing risks
survival analysis
cumulative total incidence
recurrent events
Type of item
Degree grantor
University of Alberta
Author or creator
Dong, Huiru
Supervisor and department
Yasui, Yutaka (School of Public Health)
Examining committee member and department
Jhangri, Gian (School of Public Health)
Yuan, Yan (School of Public Health)
School of Public Health Sciences
Date accepted
Graduation date
Master of Science
Degree level
In the first part of this thesis, a straightforward intuitive method for descriptive survival analysis, termed “cumulative total incidence”, is proposed to measure the total burden of recurrent events in a population by a given time. Using data from the Childhood Cancer Survivor Study, demonstrate the utility of this method contrasting this method to cumulative incidence. In the second part of this thesis, the concepts of risk and rate, and their relationship are discussed in the framework of survival analysis. Regression approaches for estimating the association between factors on event risk and event rate are discussed. Using data from the Childhood Cancer Survivor Study on two competing outcomes, we further demonstrate how competing-risk event affects the estimated association of covariates of interest with event risk and rate.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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