Download the full-sized PDF of Response of Lipid Olefinic Protons to In-Vivo Magnetic Resonance Spectroscopy  Sequences at 3 TDownload the full-sized PDF



Permanent link (DOI):


Export to: EndNote  |  Zotero  |  Mendeley


This file is in the following communities:

Graduate Studies and Research, Faculty of


This file is in the following collections:

Theses and Dissertations

Response of Lipid Olefinic Protons to In-Vivo Magnetic Resonance Spectroscopy Sequences at 3 T Open Access


Other title
olefinic protons
spinal bone marrow
magnetic resonance spectroscopy
Type of item
Degree grantor
University of Alberta
Author or creator
Bingolbali, Ayhan
Supervisor and department
Yahya, Atiyah (Oncology)
Examining committee member and department
Yahya, Atiyah (Oncology)
Wilman, Alan (Biomedical Engineering)
Jans, Hans-Sonke (Oncology)
Fallone, Gino (Oncology)
De Zanche, Nicola (Oncology)
Department of Oncology
Medical Physics
Date accepted
Graduation date
Master of Science
Degree level
Magnetic Resonance Spectroscopy (MRS) measurements of lipid unsaturation are relevant in the study of a number of diseases. The olefinic resonance yields a measure of lipid unsaturation and is often obscured by water signal in-vivo. The objective of this work is to investigate the response of lipid olefinic protons to STEAM, one of two standard in-vivo MRS methods (the other being PRESS). STEAM timing parameters were chosen (mixing time = 20 ms, echo time = 100 ms) to sufficiently resolve the olefinic resonance from that of water in-vivo while ensuring that it did not suffer significant signal losses due to J-coupling. The optimized STEAM sequence was employed to acquire signal from spinal bone marrow of four volunteers, and on average it provided 91% more olefinic signal (by area) compared to the signal acquired with a previously optimized PRESS sequence at 3 T.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 2518769
Last modified: 2015:10:12 10:47:25-06:00
Filename: Bingolbali_Ayhan_Spring 2014.pdf
Original checksum: d3ad713f5901479b58a04fee706cf0f9
Well formed: true
Valid: true
File title: Chapter 1 Basic Principles of Nuclear Magnetic Resonance
File author: ab1353
Page count: 93
File language: en-US
Activity of users you follow
User Activity Date