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Longitudinal performance of Neuropsychological Assessments in Parkinson’s Disease. Open Access


Other title
Mini-Mental State Exam
Cognitive impairment
Parkinson's Disease
Dementia Rating Scale
Clock Drawing test
Frontal Assessment Battery
Type of item
Degree grantor
University of Alberta
Author or creator
Muayqil, Taim
Supervisor and department
Senthilselvan, Ambikaipakan (Public Health Sciences)
Camicioli, Richard (Medicine)
Examining committee member and department
Senthilselvan, Ambikaipakan (Public Health Sciences)
Camicioli, Richard (Medicine)
Kalra, Sanjay (Medicine)
Jeerakathil, Thomas (Medicine)
School of Public Health Sciences
Clinical Epidemiology
Date accepted
Graduation date
Master of Science
Degree level
Parkinson’s disease (PD) involves the motor system and can lead to dementia. Dementia incidence among 102 non-demented participants (52 PD and 50 controls) followed prospectively over three years was assessed. Cognition was measured annually using the Clock Drawing Test (CDT), Mini-Mental State Exam (MMSE), Frontal Assessment Battery (FAB) and Dementia Rating Scale (DRS). Mixed-effects model was used to determine the significance of the change in neuropsychological tests (NPT) over time. Incidence of dementia in the PD group was 41.67%. The FAB and DRS showed significant. In the PD subgroup, the copy-CDT (CCDT), FAB and DRS showed decline in patients with incipient dementia (PDID). The FAB and DRS scores correlated in the primary and subgroup analyses. In the subgroup, the CCDT correlated with FAB and DRS. The NPT were useful in discriminating PD from control patients with early cognitive impairments and discriminating PDID from PDND.
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