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Genome-wide Gametic and Zygotic Linkage Disequilibrium in a Composite Beef Population Open Access


Other title
Composite Beef Population
Gametic Linkage Disequilibrium
Linkage Disequilibrium
Zygotic Linkage Disequilibrium
Type of item
Degree grantor
University of Alberta
Author or creator
Jiang, Qi
Supervisor and department
Yang, Rong-Cai (Agricultural, Food, and Nutritional Science)
Wang, Zhiquan (Agricultural, Food, and Nutritional Science)
Examining committee member and department
Yang, Rong-Cai (Agricultural, Food, and Nutritional Science)
Dixon, Walter (Agricultural, Food, and Nutritional Science)
Wang, Zhiquan (Agricultural, Food, and Nutritional Science)
Plastow, Graham (Agricultural, Food, and Nutritional Science)
Zhang, Peng (Department of Mathematical and Statistical Sciences)
Department of Agricultural, Food, and Nutritional Science
Animal Science
Date accepted
Graduation date
Master of Science
Degree level
During 1960 to 1989, the University of Alberta Kinsella Research Ranch had established synthetic beef breeds as a cost-effective crossbreeding system. Animals from these synthetics were subsequently pooled to form a composite population. Despite many breeding and genomic studies on this population, little is known about its genetic structure. This thesis provided the first genome-wide survey of linkage disequilibrium (LD) at both gametic and zygotic levels for the Kinsella population. The survey was based on the genomic data consisting of 1,023 animals genotyped for 50K SNP markers. Similar genomic structures in gametic and zygotic LD were observed, with zygotic LD decaying faster than gametic LD over marker distance. The high-order trigenic and quadrigenic disequilibria were insignificant and decayed rapidly within a very short marker distance. These results support the current intensive focus on use of high-density markers for fine-scale mapping and genomic selection in the Kinsella population.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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