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The role of novel red yeast rice formulation to modulate lipid metabolism and reduce dyslipidemia and vascular disease in the JCR:LA-cp rat Open Access


Other title
chylomicron remnant
red yeast rice
Type of item
Degree grantor
University of Alberta
Author or creator
Wu, Sheng
Supervisor and department
Spencer Proctor (Agricultural, Food, and Nutritional Science)
Examining committee member and department
Tom Clandinin (Medicine; Agricultural, Food, and Nutritional Science)
Donna Vine (Agricultural, Food, and Nutritional Science)
Spencer Proctor (Agricultural, Food, and Nutritional Science)
Department of Agricultural, Food, and Nutritional Science
Nutrition and metabolism
Date accepted
Graduation date
Master of Science
Degree level
Liver derived low-density lipoprotein and intestinal derived chylomicron remnant are contributors to dyslipidemia and cardiovascular disease (CVD). In clinical practice, the most common medication to reduce fasting LDL-cholesterol is statins. However, for many individuals prescribed statins, a substantial ‘residual risk’ of CVD remains. Therefore, effective nutraceutical approaches that have multiple targets to lower cholesterol secreted by both the liver and the intestine remain attractive. The objective was to assess the lipid lowering efficacy of novel formulations: chitin-glucan, phytosterol, the red yeast rice, using a rodent model of dyslipidemia. It was observed that these active ingredients all independently reduced fasting plasma lipids. Further, the combination of these ingredients, with 1mg/kg red yeast rice, was the most effective at reducing both fasting and non-fasting plasma lipids. The findings provide pre-clinical support for the combined use of these ingredients as a nutraceutical alternative to classic lipid lowering pharmacotherapies.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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