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Photothermal effects and mesoporous silica encapsulation of silicon nanocrystals Open Access
- Other title
mesoporous silica encapsulation
- Type of item
- Degree grantor
University of Alberta
- Author or creator
- Supervisor and department
Veinot, Jonathan G.C. (Chemistry)
- Examining committee member and department
Gibbs-Davis, Julianne (Chemistry)
Hegmann, Frank (Physics)
Department of Chemistry
- Date accepted
- Graduation date
Master of Science
- Degree level
The present thesis describes preliminary studies required for evaluating silicon nanocrystals (Si-NCs) as photothermal (PT) therapy agents and drug delivery vehicles. Group 14 semiconductor NCs are of particular interest for these applications because of their tailorable optical response and biological inertness.
Detailed studies of the PT efficiencies of different sized Si-NCs were performed. It was found the PT response exhibited by the presented Si-NCs showed a clear size dependence leading to the proposal that its origin is dominant due to the phenomenon of carrier cooling.
Mesoporous silica is a promising material for drug delivery applications because of its intrinsic high surface area and tailorable pore size. A surfactant-templated approach is described within this thesis that affords effective encapsulation of Si-NCs within 30 nm mesoporous silica nanospheres, The resulting photoluminescent particles were evaluated in proof-of-concept drug release investigations.
- Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
- Citation for previous publication
Regli, Sarah (2011). MRS proceedings http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8279193&fulltextType=RA&fileId=S1946427411007846
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File author: Sarah Regli
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