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Photothermal effects and mesoporous silica encapsulation of silicon nanocrystals Open Access

Descriptions

Other title
Subject/Keyword
mesoporous silica encapsulation
photoluminescence
drug-delivery
photothermal
multifunctional materials
silicon nanocrystals
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Regli, Sarah
Supervisor and department
Veinot, Jonathan G.C. (Chemistry)
Examining committee member and department
Gibbs-Davis, Julianne (Chemistry)
Hegmann, Frank (Physics)
Department
Department of Chemistry
Specialization

Date accepted
2012-05-31T15:16:46Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
The present thesis describes preliminary studies required for evaluating silicon nanocrystals (Si-NCs) as photothermal (PT) therapy agents and drug delivery vehicles. Group 14 semiconductor NCs are of particular interest for these applications because of their tailorable optical response and biological inertness. Detailed studies of the PT efficiencies of different sized Si-NCs were performed. It was found the PT response exhibited by the presented Si-NCs showed a clear size dependence leading to the proposal that its origin is dominant due to the phenomenon of carrier cooling. Mesoporous silica is a promising material for drug delivery applications because of its intrinsic high surface area and tailorable pore size. A surfactant-templated approach is described within this thesis that affords effective encapsulation of Si-NCs within 30 nm mesoporous silica nanospheres, The resulting photoluminescent particles were evaluated in proof-of-concept drug release investigations.
Language
English
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Regli, Sarah (2011). MRS proceedings http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8279193&fulltextType=RA&fileId=S1946427411007846

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File size: 62088227
Last modified: 2015:10:12 16:37:24-06:00
Filename: Regli_Sarah_Spring 2012.pdf
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Status message: File header gives version as 1.4, but catalog dictionary gives version as 1.3
File title: Title
File author: Sarah Regli
Page count: 131
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