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The role of penicillin G potassium in managing Clostridium perfringens in broiler chickens Open Access


Author or creator
Gadbois, Pierre
Brennan, J.
Bruce, Heather
Wilson, J.
Aramini, Jeff
Additional contributors
Broiler Chicken
Clostridium Perfringens
Penicillin G Potassium
Necrotic Enteritis
Type of item
Journal Article (Published)
The efficacy of penicillin G potassium (Pot-Pen) administered via drinking water to manage necrotic enteritis (NE) was investigated in a Clostridium perfringens (CP) challenge study using 1600 broiler chickens assigned to one of four treatment groups: nonchallenged, nonmedicated; challenged, nonmedicated; challenged, Pot-Pen 0.2 g/L; challenged, Pot-Pen 0.4 g/L. Overall mortality due to NE was significantly reduced among Pot-Pen–treated pens; mortality due to other causes did not differ among the treatment groups. Among all birds, growth performance parameters were significantly improved among Pot-Pen–treated pens. When considering birds randomly sacrificed 4 days post-Pot-Pen initiation, mean NE lesion scores were greatest among the challenged, nonmedicated pens; only one of 80 randomly sacrificed birds treated with Pot-Pen had NE lesions. Among the nonmedicated control pens, body weight (BW) was significantly greater among birds that did not have NE-associated lesions. When sacrificed birds were stratified by NE lesion score, there were no significant differences in BW among the treatment groups. Results of this study suggest that CP-associated subclinical disease can significantly reduce broiler performance. Furthermore, the positive effects of treatment with Pot-Pen appeared to be associated with the prevention and/or treatment of NE-specific lesions.
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© 2008 Pierre Gadbois et al. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.

Citation for previous publication
Gadbois, P., Brennan, J., Bruce, H., Wilson, J., & Aramini, J. (2008). The role of penicillin G potassium in managing Clostridium perfringens in broiler chickens. Avian Diseases, 52(3), 407-411.


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