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Real Time Tracking of Lung Tumours Using Low Field MRI: A Feasibility Study Open Access


Other title
Magnetic Resonance Imaging
MR Tumour Tracking
Image Guidance
Type of item
Degree grantor
University of Alberta
Author or creator
Yip, Eugene
Supervisor and department
Wachowicz, Keith (Oncology)
Fallone, B. Gino (Oncology, Physics)
Rathee, Satyapal (Oncology)
Examining committee member and department
De Zanche, Nicola (Oncology)
Thompson, Richard (Biomedical Engineering)
Yahya, Atiyah (Oncology)
Department of Oncology
Medical Physics
Date accepted
Graduation date
Master of Science
Degree level
The aim of this work is to evaluate the feasibility of low field MR based real time lung tumour tracking, a promising application of proposed linac-MR system. In this work, motion phantoms replicating low field MR contrast parameters for thoracic anatomy of lung cancer patients are imaged with fast imaging sequences in 3 T MRI. Noise is added to generate "low field equivalent" images. Using these phantom images, the accuracy of auto-segmentation was demonstrated by comparing the determined tumour shapes against reference shapes, and by comparing the determined tumour location against the independently measured reference tumour motion trajectory. Low field equivalent images are also generated for a lung cancer patient, and the tumour’s shape and location determined via auto-segmentation. Low field MRI shows promise in terms of determining the shape and location of tumour in real-time such that it is feasible to track the moving tumours in real-time.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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