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Permanent link (DOI): https://doi.org/10.7939/R3RT33

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Mechanistic Insight Into the Role of FABP7 in Malignant Glioma Open Access

Descriptions

Other title
Subject/Keyword
Brain fatty acid-binding protein
COX-2
arachidonic acid
Nuclear phospholipids
docosahexaenoic acid
FABP7
Glioma
Treatment of glioma with fatty acids
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Beaulieu, Michael J.
Supervisor and department
Roseline Godbout (Oncology)
Examining committee member and department
David Brindley (Biochemistry)
Albert Murtha (Oncology)
Andrew Shaw (Oncology)
Department
Department of Oncology
Specialization
Experimental Oncology
Date accepted
2012-08-31T12:42:43Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of FABP7-positive MG cells is mediated by ligands of FABP7. We hypothesize that FABP7 plays a central role in stabilizing the aggressive behaviour of MG cells in a manner that is dependent on the COX-2 pathway. Here, we demonstrate that FABP7 alters the gene expression profile of MG cells, and the expression of potent inflammatory mediators. We provide evidence for a ligand-specific interaction between FABP7 and PPAR-β/δ, which could have consequences in mediating FABP7- dependent gene expression. We also demonstrate a role for FABP7 in modulating the AA and DHA content of nuclear phospholipid classes, and suggest that DHA maybe useful for treatment of MG.
Language
English
DOI
doi:10.7939/R3RT33
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Liu, R.Z., Mita, R., Beaulieu, M., Gao, Z., and Godbout, R. (2010). Fatty acid binding proteins in brain development and disease. Int J Dev Biol 54, 1229-1239.Mita, R., Beaulieu, M.J., Field, C., and Godbout, R. (2010). Brain fatty acid-binding protein and omega-3/omega-6 fatty acids: mechanistic insight into malignant glioma cell migration. J Biol Chem 285, 37005-37015.

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