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Permanent link (DOI): https://doi.org/10.7939/R3RT33
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Mechanistic Insight Into the Role of FABP7 in Malignant Glioma Open Access
- Other title
Brain fatty acid-binding protein
Treatment of glioma with fatty acids
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Beaulieu, Michael J.
- Supervisor and department
Roseline Godbout (Oncology)
- Examining committee member and department
David Brindley (Biochemistry)
Albert Murtha (Oncology)
Andrew Shaw (Oncology)
Department of Oncology
- Date accepted
- Graduation date
Master of Science
- Degree level
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the
migratory behaviour of FABP7-positive MG cells is mediated by ligands of FABP7. We hypothesize that FABP7 plays a central role in stabilizing the aggressive behaviour of MG cells in a manner that is dependent on the COX-2 pathway.
Here, we demonstrate that FABP7 alters the gene expression profile of MG cells, and the expression of potent inflammatory mediators. We provide evidence for a ligand-specific interaction between FABP7 and PPAR-β/δ, which could have consequences in mediating FABP7- dependent gene expression. We also demonstrate a role for FABP7 in modulating the AA and DHA content of nuclear phospholipid classes, and suggest that DHA maybe useful for treatment of MG.
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- Citation for previous publication
Liu, R.Z., Mita, R., Beaulieu, M., Gao, Z., and Godbout, R. (2010). Fatty acid binding proteins in brain development and disease. Int J Dev Biol 54, 1229-1239.Mita, R., Beaulieu, M.J., Field, C., and Godbout, R. (2010). Brain fatty acid-binding protein and omega-3/omega-6 fatty acids: mechanistic insight into malignant glioma cell migration. J Biol Chem 285, 37005-37015.
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