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Annihilation of cardiac alternans by electric and mechano-electric feedback (MEF) in a cardiac tissue Open Access


Other title
model based control
mechano-electric feedback
Type of item
Degree grantor
University of Alberta
Author or creator
Deshpande, Dipen
Supervisor and department
Dubljevic, Stevan (Chemical and Materials Engineering)
Examining committee member and department
Belhamadia, Youssef (Mathematics, Campus Saint-Jean)
Shah, Sirish (Chemical and Materials Engineering)
Yeung, Tony (Chemical and Materials Engineering)
Department of Chemical and Materials Engineering

Date accepted
Graduation date
Master of Science
Degree level
Alternans occur prior to ventricular fibrillation and is a medical condition of heart that leads to sudden cardiac death (SCD). The presence of the electrical alternans induces, through the mechanism of the excitation-contraction coupling, an alternation in the heart muscle contractile activity. This work provides a study on the cardiac alternans annihilation by applied electrical and mechanical perturbation. In particular, we address annihilation of alternans in medically relevant size heart tissue by considering modulation of ionic cur- rents in Luo-Rudy-1 (LR1) cardiac cell model, in which the control algorithm involves a combined electrical boundary pacing control and a spatially distributed calcium based control which perturbs the calcium in the cells. A parabolic partial differential equation (PDE) which is adapted from the ionic model is investigated to get an insight in terms of the controllability and stabilizability of the tissue for the suggested control input. Compli- mentary to this, we also address a novel mechanism of alternans annihilation which uses a Nash-Panfilov model coupled with the stress equilibrium equations. The coupled model includes an additional variable to represent the active stress which defines the mechanical properties of the tissue and is utilized in the feedback algorithm as an independent input from the pacing based controller realization in alternans annihilation.
License granted by Dipen Deshpande ( on 2011-09-27T21:53:24Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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