Alberta Research Centre for Health Evidence (ARCHE)
The Alberta Research Centre for Health Evidence (ARCHE), located within the Department of Pediatrics at the University of Alberta, was established in 2000 to serve as a resource to individuals and groups interested in using evidence for decision making.
The mandate of ARCHE is to support and foster the development of evidence-informed practice. To achieve this, ARCHE:
- produces high quality evidence syntheses aimed at high priority issues in health;
- advances the methods of conducting randomized controlled trials (RCTs) and evidence syntheses;
- provides training and mentoring to health care professionals, trainees and students;
- conducts knowledge translation activities to help inform clinical and policy decisions.
Items in this Collection
- 12Systematic reviews
- 9Pediatrics
- 5Child health
- 5Randomized controlled trials
- 4Drug therapy
- 4Meta-analysis
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Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.
Download2006
Vandermeer, B., Hartling, L., Buscemi, N.., Baker, G., Klassen, T. P., Vohra, S., Pandya, R., Tjosvold, L., Hooton, N.
Objective To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. Data sources 13 electronic databases and reference lists of relevant...
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2013-02-15
Klassen, Terry P., Plint, Amy C., Vandermeer, Ben, Tjosvold, Lisa, Hartling, Lisa, Fernandes, Ricardo M., Patel, Hema, Bialy, Liza M., Johnson, David W.
Background: Bronchodilators are commonly used for acute bronchiolitis, despite uncertain effectiveness. Objectives: To examine the efficacy and safety of epinephrine in children less than two with acute viral bronchiolitis. Search methods: We searched CENTRAL (2010, Issue 3) which contains the...
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From the trenches: a cross-sectional study applying the GRADE tool in systematic reviews of healthcare interventions.
Download2012
Dryden, D. M., Vandermeer, B., Seida, J., Hartling, L., Fernandes, R. M.
Background GRADE was developed to address shortcomings of tools to rate the quality of a body of evidence. While much has been published about GRADE, there are few empirical and systematic evaluations. Objective To assess GRADE for systematic reviews (SRs) in terms of inter-rater agreement and...
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2013-02-15
Tjosvold, Lisa, Klassen, Terry P., Bialy, Liza M., Hartling, Lisa, Vandermeer, Ben, Johnson, David W., Patel, Hema, Plint, Amy C., Fernandes, Ricardo M.
BACKGROUND: Previous systematic reviews have not shown clear benefit of glucocorticoids for acute viral bronchiolitis, but their use remains considerable. Recent large trials add substantially to current evidence and suggest novel glucocorticoid-including treatment approaches. OBJECTIVES: To...
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2015/18/12
Introduction: Non-invasive ventilation (NIV) in children has become an increasingly common modality of breathing support where pressure support is delivered through a mask interface or less commonly through other non-invasive interfaces. At this time, NIV is considered a first-line option for...
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2013-02-15
Joffe, Ari, Vandermeer, Ben, Hartling, Lisa, Lequier, Laurance, Larsen, Bodil, Anton, Natalie, Tjosvold, Lisa
Background: Nutritional support in the critically ill child has not been well investigated and is a controversial topic within paediatric intensive care. There are no clear guidelines as to the best form or timing of nutrition in critically ill infants and children. Objectives: To assess the...
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Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials.
Download2004
Klassen, T. P., McConnell, D., Craig, W. R., Wiebe, N., Hartling, L., Bellemare, S., Russell, K.
Background Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy...
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Quantifying bias in randomized controlled trials in child health: a meta-epidemiological study.
Download2014
Hartling, L., Vandermeer, B., Dryden, D. M., Fernandes, R. M., Hamm, M. P.
Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...