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Journal Articles (Chemistry)
Items in this Collection
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2017-01-01
El-Yazbi, Amira F., Wong, Alysha, Loppnow, Glen R.
The human genome is susceptible to change; base mismatches can arise from damaged DNA, replication errors, and spontaneous mutation, and have the potential to cause apoptosis, carcinogenesis, and mutagenesis. Many techniques have been developed for DNA mismatch detection, but many of these...
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2013-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Absorption of UV light by nucleic acids can result in the formation of molecular lesions in DNA and RNA, leading to mutagenesis, carcinogenesis, and cell death. In this work, hairpin oligonucleotide probes, which have previously been shown to be selective for DNA damage, are used. The hypochromic...
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2014-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Nucleic acids (NAs) play a vital role in numerous biological processes. Absorption of ultraviolet (UV) light by NAs can result in DNA damage at the molecular level, leading to mutagenesis, carcinogenesis, and cell death. Thus, much effort has been focused on developing methods for detecting...
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2018-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Hepatocellular carcinoma is one of the most common malignant tumors in the world. Chronic hepatitis B and C infections are the most common etiologies of hepatocellular carcinoma worldwide. In this study, we explore the potential DNA damaging effect of some FDA-approved antiviral drugs which may...
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Terbium fluorescence as a sensitive, inexpensive probe for UV-induced damage in nucleic acids
Download2013-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Much effort has been focused on developing methods for detecting damaged nucleic acids. However, almost all of the proposed methods consist of multi-step procedures, are limited, require expensive instruments, or suffer from a high level of interferences. In this paper, we present a novel simple,...