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Journal Articles (Chemistry)
Items in this Collection
- 13Macauley, Matthew S.
- 3Arlian, Britni M.
- 3He, Yuan
- 2Davies, Gideon J.
- 2Errington, Wesley J.
- 2Mackereth, Cameron D.
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2016
O’Dwyer, Michael E., Macauley, Matthew S., Natoni, Alessandro
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...
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2015
Xiao, Changchun., Gonzalez-Martin, Alicia, Miletic, Ana V., Rickert, Robert C., Head, Steven R., Knight, Sarah, , Macauley, Matthew S., Lai, Maoyi, Jin, Hyun Y., Sabouri-Ghomi, Mohsen
Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used extensively to study the functions and mechanisms of endogenous miRNAs. However, it remains unclear whether transfected miRNAs behave similarly to endogenous miRNAs. Here we show that transient transfection of...
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Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man
Download2015
McBride, Ryan, Wang, Shui-Hua , Macauley, Matthew S., Khoo, Kay-Hooi, Paulson, James C., Kannagi, Reiji, Peng, Wenjie, He, Yuan, Kawasaki, Norihito, Arlian, Britni M.
CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence. Here, we show in both mice and humans that loss of high affinity...