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Journal Articles (Chemistry)
Items in this Collection
- 2Macauley, Matthew S.
- 2Paulson, James C.
- 1Arlian, Britni M.
- 1Gale, Andrew J.
- 1He, Yuan
- 1Kannagi, Reiji
- 1Autoimmune-Disease
- 1Carbohydrate-Binding Protein
- 1Cd22?Siglec
- 1Germinalcenter
- 1Glycans
- 1Glycobiology
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2013
Pfrengle, Fabian, Paulson, James C., Gale, Andrew J., Nycholat, Corwin M., von Drygalski, Annette, Rademacher, Christoph, Macauley, Matthew S.
Antibodies confer humoral immunity but can also be harmful when they target an autoantigen, alloantigen, allergen, or biotherapeutic. New strategies are needed for antigen-specific suppression of undesired antibody responses, particularly to T cell–dependent protein antigens, because they elicit...
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Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man
Download2015
McBride, Ryan, Wang, Shui-Hua , Macauley, Matthew S., Khoo, Kay-Hooi, Paulson, James C., Kannagi, Reiji, Peng, Wenjie, He, Yuan, Kawasaki, Norihito, Arlian, Britni M.
CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence. Here, we show in both mice and humans that loss of high affinity...