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Journal Articles (Chemistry)
Items in this Collection
- 2Macauley, Matthew S.
- 1Arlian, Britni M.
- 1Chin, Danielle
- 1Debowski, Aleksandra W.
- 1Fokin, Valery V.
- 1He, Yuan
- 2Alzheimers-Disease
- 1Antigen; Binding
- 1Beta-D-Glucosaminidase
- 1Crystal-Structure
- 1Cytosolic Proteins
- 1Diabetogenic Action
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Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas
Download2014
McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik
The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...
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O-GlcNAcase uses substrate-assisted catalysis Kinetic analysis and development of highly selective mechanism-inspired inhibitors
Download2005
Vocadlo, David J., Whitworth, Garrett E., Macauley, Matthew S., Debowski, Aleksandra W., Chin, Danielle
The post-translational modification of serine and threonine residues of nucleocytoplasmic proteins with 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc) is a reversible process implicated in multiple cellular processes. The enzyme O-GlcNAcase catalyzes the cleavage of β-O-linked GlcNAc (O-GlcNAc)...