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Journal Articles (Chemistry)
Items in this Collection
- 1Arlian, Britni M.
- 1Fokin, Valery V.
- 1He, Yuan
- 1Macauley, Matthew S.
- 1McBride, Ryan
- 1Paulson, James C.
- 1Alzheimers-Disease
- 1Antigen; Binding
- 1Gemtuzumab Ozogamicin
- 1High-Affinity Ligand
- 1Identification
- 1Inotuzumab Ozogamicin
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Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas
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McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik
The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...