Journal Articles (Agricultural, Food and Nutritional Science)
Items in this Collection
- 7Gänzle, Michael G.
- 5Willing, Benjamin P.
- 3Finlay, B. Brett
- 2Antunes, L. Caetano M.
- 2Croxen, Matthew A.
- 2Dieleman, Levinus A.
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Use of the fluorescent probe LAURDAN to label and measure inner membrane fluidity of endospores of Clostridium spp.
Download2012-10-01
Hofstetter, Simmon, Denter, Christian, Winter, Roland, McMullen, Lynn M., Gänzle, Michael G.
A method for measuring the fluidity of inner membranes of populations of endospores of Clostridium spp. with a fluorescent dye was developed. Cells of Clostridium beijerinckii ATCC 8260 and Clostridium sporogenes ATCC 7955 were allowed to sporulate in the presence of...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization
Download2011
Antunes, L. Caetano M., Gill, Navkiran, Russell, Shannon L., Finlay, B. Brett, Ferreira, Rosana B., Croxen, Matthew A., Willing, Benjamin P.
The intestinal microbiota is composed of hundreds of species of bacteria, fungi and protozoa and is critical for numerous biological processes, such as nutrient acquisition, vitamin production, and colonization resistance against bacterial pathogens. We studied the role of the intestinal...
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Small intestine early innate immunity response during intestinal colonization by Escherichia coli depends on its extra-intestinal virulence status
Download2016
Denamur, Erick, Tourret, Jérôme, Dion, Sara, Willing, Benjamin P., Wachtel, Sarah, Finlay, B. Brett, Dufour, Nicolas, Croxen, Matthew A.
Uropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in the digestive tract. Mice were orally challenged...
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Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization
Download2012
Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...
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Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
Download2012
Rang, Sara, Roos, Stefan, Phillipson, Mia, Holm, Lena, Dicksved, Johan, Willing, Ben P., Petersson, Joel, Schreiber, Olof
Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS)-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective...
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
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Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome
Download2013-01-01
Thiesen, Aducio, Rioux, Kevin P., Tso, Robert, Kish, Lisa, Barkema, Herman W., Madsen, Karen L., Vincent, Renaud, Wine, Eytan, Kaplan, Gilaad G., Hotte, Naomi, Gänzle, Michael G.
Background Particulate matter (PM) is a key pollutant in ambient air that has been associated with negative health conditions in urban environments. The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory...
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Effects of nisin and reutericyclin on resistance of endospores of Clostridium spp. to heat and high pressure
Download2013-05-01
Hofstetter, Simmon, Gebhardt, David, Ho, Linda, Gänzle, Michael G., McMullen, Lynn M.
The effects of high pressure, temperature, and antimicrobial compounds on endospores of Clostridium spp. were examined. Minimal inhibitory concentrations (MIC) of nisin and reutericyclin were determined for vegetative cells and endospores of Clostridium sporogenes ATCC 7955, Clostridium...
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Diet and environment shape fecal bacterial microbiota composition and enteric pathogen load of grizzly bears
Download2011-01-01
Northrup, Joseph M., Cristescu, Bogdan, Schwab, Clarissa, Stenhouse, Gordon B., Gänzle, Michael G.
Background Diet and environment impact the composition of mammalian intestinal microbiota; dietary or health disturbances trigger alterations in intestinal microbiota composition and render the host susceptible to enteric pathogens. To date no long term monitoring data exist on the fecal...