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Medical Oncology
The Division of Medical Oncology focuses on systemic therapy for patients with cancer. We are actively involved in improving the outcome of patients through research and quality improvement programs. Members of the Division are responsible for education and training of undergraduate and postgraduate students and the continuous professional development of practitioners.
Items in this Collection
- 2Tuszynski, Jack A.
- 1Ayoub, Ahmed T.
- 1Dumontet , Charles
- 1Ghosh, Sunita
- 1Graham, Kathryn
- 1Katsetos, Christos D.
- 1Anti-tumor drugs
- 1Binding site
- 1Breast cancer
- 1C.autumnale
- 1Cancer-associated mutations
- 1Colchicine
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Spasevska, Ivana , Wong, Gane K.-S. , Preto, Jordane , Winter, Philip , Dumontet , Charles , Ayoub, Ahmed T. , Tuszynski, Jack A.
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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2016-12-09
Winter, Philip, Wang, Xumin, Mackey, John R. , Lee, John C. , Wong, Gane Ka-Shu, Ghosh, Sunita, Patterson, Jordan, Zhang, Hangxiao, Wang, Weiwei, Tuszynski, Jack A. , Katsetos, Christos D., Graham, Kathryn, Luduena, Richard F.
Tubulin is the target for very widely used anti-tumor drugs, including Vinca alkaloids, taxanes, and epothilones, which are an important component of chemotherapy in breast cancer and other malignancies. Paclitaxel and other tubulin-targeting drugs bind to the β subunit of tubulin, which is a...