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Skip to Search Results- 1Al Yousef, Habib Saleh M
- 1Armstrong, Stephen, R.
- 1Freschauf, Gary
- 1Jiang, Bingcheng
- 1Locke, Andrew J
- 1Mereniuk, Todd
- 4DNA repair
- 2Polynucleotide kinase/phosphatase
- 2Synthetic lethality
- 2phosphorylation
- 1ATM-deficient cells
- 1ATM-independent
Results for "supervisors_tesim:"Weinfeld, Michael (Oncology)""
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Evaluating the consequences of polynucleotide kinase/phosphatase (PNKP) mutations in neurological diseases
DownloadSpring 2022
Genomic stability is extremely important for developing or maintaining normal neurological functions, as the nervous system is constantly suffering from endogenous DNA damage. To maintain such stability, living cells are protected by several different DNA repair pathways. Polynucleotide...
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Identification of small molecule inhibitors of the human DNA repair enzyme polynucleotide kinase/phosphatase
DownloadFall 2011
Human polynucleotide kinase/phosphatase (hPNKP) is a bifunctional DNA repair enzyme that phosphorylates DNA 5’-termini and dephosphorylates DNA 3’-termini. hPNKP has been shown to be involved in both single- and double-strand break repair, and cancer cells depleted of hPNKP show significant...
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Evaluation of bioreductively-activated Tirapazamine (TPZ) prodrugs for the management of hypoxic solid tumors
DownloadFall 2019
Solid tumors often have large areas with low levels of oxygen (termed hypoxic regions), which are associated with poor prognosis and treatment response. Tirapazamine (TPZ), a hypoxia targeting anticancer drug, started as a promising candidate to deal with this issue. However, it was withdrawn...
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Novel Therapeutic Approaches for Cancer Therapy Based on Targeting the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase
DownloadFall 2018
The relentless growth of tumors is triggered by a complex array of molecular changes such as DNA damage, disruption of cell-cycle progression, uncontrolled proliferation and escaping cell death. Various therapies have been developed to treat cancer, many of which kill cancer cells by damaging...
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Investigation of the role of UBE4B ubiquitin ligase in p53 regulation in response to DNA damage in ATM-proficient and ATM-deficient cells
DownloadFall 2017
The tumour suppressor protein p53 maintains genomic integrity by coordinating the DNA damage response, which includes growth arrest, DNA damage repair, and apoptotic cell death. p53 is mutated in more than 50% of human cancer, which reflects its importance. The complex mechanism that controls the...
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Fall 2016
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...
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Spring 2024
DNA double-strand breaks (DSBs) are considered the most deleterious DNA lesions. Unrepaired or incorrectly repaired DSBs can lead to cell cycle arrest, apoptosis, or over time, the accumulation of mutations and chromosomal abnormalities that give rise to cancer. The repair of DSBs by homologous...
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Synthetic lethal targeting of polynucleotide kinase/phosphatase and its potential role in directed cancer therapies
DownloadFall 2012
Synthetic lethality arises when simultaneous disruption of two non-essential, non-allelic genes in the same cell causes lethality. This phenomenon has been shown to occur between proteins involved in DNA repair and much attention to date has focused on poly(ADP-ribose) polymerase and the BRCA...