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Skip to Search ResultsResults for "supervisors_tesim:"Velazquez, Carlos (Faculty of Pharmacy and Pharmaceutical Sciences)""
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Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factor
DownloadFall 2017
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
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Downregulation of the FOXM1 transcription factor by dual nitric oxide-/ hydrogen sulfide-donors: preliminary structure-activity relationships
DownloadFall 2015
Rodriguez Dimitrescu, Alexandra
In recent decades, the Forkhead Box (FOX) family of transcription factors (e.g. FOXM1) has attracted the attention of the scientific community due to its significant role in cancer initiation and progression. Furthermore, the abnormal or deregulated expression of FOXM1 has been associated with...
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Study of resveratrol-salicylate hybrid analogues: design, synthesis and their biological evaluation as potential multi-target chemopreventive agents
DownloadSpring 2016
Nature is an important source of bioactive molecules with favorable biological properties. Resveratrol is a natural compound found in grapes and berries and is among other constituents of red wine. This polyphenol has been studied and extensively reported in the literature. Resveratrol exerts a...