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Skip to Search Results- 1Beatrice Adamptey
- 1Benson, Matthew David
- 1Crichton,Paul
- 1Dimopoulos, Ioannis
- 1Dornstauder, Blake
- 1Freund, Paul R
- 1Lemieux, Helene (Faculty Saint-Jean)
- 1MacDonald, Ian (Medical Sciences- Ophthalmology and Visual Sciences)
- 1MacDonald, Ian (Medical Sciences-Ophthalmology)
- 1MacDonald, Ian (Ophthalmology & Visual Sciences)
- 1MacDonald, Ian (Ophthalmology and Visual Sciences)
- 1MacDonald, Ian (Ophthalmology)
Results for "departments_tesim:"Medical Sciences-Ophthalmology""
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Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the Retina
DownloadFall 2022
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
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Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications
DownloadFall 2014
Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on...
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Spring 2011
Age-related macular degeneration (AMD) is the leading cause of Government-registered blindness in the elderly of the Western world and has two forms: wet and dry. No current AMD therapies are curative, and most are provided after retinal damage from the disease has already occurred (to preserve...
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Fall 2014
Choroideremia (CHM) is an inherited X-linked retinal dystrophy that causes hemizygous males to develop nyctalopia and a progressive loss of their peripheral visual field until only central vision remains. At the end stages of the degeneration, central acuity is also affected. The onset and rate...
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Changes in Retinal Mitochondrial Function in Ocular Diseases and a Potential Treatment Using Near-Infrared Light
DownloadFall 2018
Mitochondria are both prominent target and source of reactive oxygen species (ROS). Their role in a wide range of diseases has been gaining a substantial amount of interest, including a number of high-profile ocular diseases. In the present thesis, we investigated the mitochondrial functional...
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Spring 2021
Purpose. Peroxisomal biogenesis disorders (PBDs) represent a group of recessive conditions that cause severe vision loss, sensorineural hearing loss, neurologic dysfunction, and other systemic abnormalities due to abnormal peroxisomal function. Appropriate therapies are needed as there are no...
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The risk of hydroxychloroquine retinopathy and the role of the multifocal electroretinogram in screening and monitoring retinal toxicity
DownloadFall 2018
Background: Hydroxychloroquine sulfate (Plaquenil) is a useful, inexpensive drug with a high systemic safety profile. Prolonged use of Plaquenil however causes toxic effects on ocular structures, including the retina. The aim of this study was to determine the role of the multifocal...