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Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...
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β-catenin is O-GlcNAc modified at Serine 23: Implications for β-catenin’s Subcellular Distribution and Transcriptional Activity
DownloadFall 2012
β-catenin is a potent oncoprotein that serves as a structural anchor at the adherens junctions and as a transcriptional co-activator of the Wnt Signaling pathway. β-catenin was identified to be post-translationally modified by O-linked β-D-N-acetyl-glucosamine (O-GlcNAc). This investigation was...