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The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation
DownloadSpring 2016
Mercer, Robert Corrigan Curtis
Prion diseases are invariably fatal neurodegenerative diseases of humans and other mammals. While they can manifest as sporadic, infectious or genetic etiologies, the central event in prion disease is the structural conversion of the prion protein (PrPC) to an alternative conformer PrPSc. PrP is...
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Spring 2016
In undergraduate education, nurse educators have embraced preceptorship as a teaching/learning approach in preparing nursing students for professional practice. As educational institutions broaden their international agenda to include borderless or global nursing placements, a thorough...
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The Pursuit of Noh-ledge
2016
Kata, or fixed patterns, are an element of performance seemingly unique to the Japanese theatre tradition. To further investigate this phenomenon, I am tracing it back to what I believe is its genesis in medieval noh theatre. This is represented here by a ko-omote mask, of which both the inside...
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2016-01-01
Kata, or fixed patterns, are an element of performance seemingly unique to the Japanese theatre tradition. To further investigate this phenomenon, I am tracing it back to what I believe is its genesis in medieval noh theatre. This is represented here by a ko-omote mask, of which both the inside...
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Fall 2016
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous plasma membrane protein that regulates intracellular pH by removing a proton in exchange for extracellular sodium. NHE1 is expressed in many tissues including the kidney where it has been demonstrated to play essential roles in pH...
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The Regulation of p53 by E3 ligases MDM2 and CHIP in Breast Cancer: Analysis of the Role of Hsp70 and Hsp90
DownloadSpring 2016
Tumor suppressor p53 is commonly mutated in breast cancer. Mutant p53 protein is highly stable and oncogenic. This study aims to understand the underlying mechanism of the regulation and stabilization of mutant p53 protein particularly folded mutant p53 R280K. The data showed a possible...
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2016
This paper describes a study that explores the relation between high-school students’ feedback choices, memory for these feedback choices, and task performance. Choices to seek confirmatory (positive) or critical (negative) feedback and to revise posters in a poster design task were collected...
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Fall 2016
Relative to those without diabetes, individuals with type 2 diabetes have an increased risk of several cancers, but a decreased risk of prostate cancer. While metformin may reduce the risk of some cancers, it may not reduce the risk of prostate cancer. However, race/ethnicity may modify...
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Fall 2016
Depression a disabling chronic illness that crosses borders, cultures, and elements of society. It is well known that there are a number of risk factors for depression including younger age, racial minority status, female sex, presence of substance abuse disorders, chronic illness, and lower...