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Membrane Type 1 Matrix Metalloproteinase Cleaves Low Density Lipoprotein Receptor to Regulate Lipid Metabolism
DownloadFall 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol (LDL-C) and protects against the development of atherosclerosis. Our previous studies demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP14) cleaves LDL receptor (LDLR) and exacerbates the...
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Membrane Type 1-Matrix Metalloproteinase Mediates Degradation of the Low-density Lipoprotein Receptor Family Members
DownloadSpring 2024
The low-density lipoprotein receptor (LDLR) family includes 13 transmembrane protein members sharing a conserved structure and common repeats. Their importance has been shown in a variety of physiological and pathophysiological events including lipid metabolism, nervous system development and...