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Spring 2018
Introduction: Asthma is a chronic inflammatory disease characterized by intermittent episodes of acute airway inflammation and bronchoconstriction. Although asthma is generally considered a disease of the airways, asthma is also associated with an increased risk of developing cardiovascular (CV)...
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The Effect of Pulmonary Rehabilitation on Carotid Chemoreceptor Activity and Sensitivity in Chronic Obstructive Pulmonary Disease
DownloadSpring 2017
Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular (CV) risk, which may result from heightened sympathetic nerve activity secondary to elevated carotid chemoreceptor (CC) activity/sensitivity. Our recent work indicates that CC activity/sensitivity is elevated...
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The effects of carotid chemoreceptor inhibition on exercise tolerance in health and chronic heart failure
DownloadFall 2018
Background and Rationale: Chronic heart failure (CHF) is a condition where heart function is insufficient to meet metabolic demand and is caused by anatomical or physiological abnormalities of the heart. In 2009, one in nine deaths included heart failure as a contributing cause, and the five-year...
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Understanding the impact of pulmonary vascular structure and function on exercise tolerance and dyspnea in health and chronic obstructive pulmonary disease
DownloadSpring 2024
The purpose of this dissertation was to examine pulmonary vascular structure and function and its relationship with exercise capacity in individuals with and without chronic obstructive pulmonary disease (COPD). We hypothesized that pulmonary vascular structure and function play a key role in...
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Fall 2014
The purpose of this experiment was to study breathing pattern, operational lung volume and respiratory muscle strength during 45 minutes of exercise with a heavy backpack (25 kg). Fifteen males completed randomly ordered graded exercise tests on a treadmill with (L) and without (U) a correctly...