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Epigenetic Involvement in Heterosynaptic (Tagged) LTP Following Beta-Adrenergic Receptor Activation in the Mouse Hippocampus
DownloadSpring 2019
Synapses experience long-lasting plastic changes following neuromodulatory action in the brain. One natural modulator is noradrenaline (NA). Beta-adrenergic receptor (b-AR) activation by noradrenaline enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity...
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Mechanisms involved in the norepinephrine-mediated protection of synapses from depotentiation
DownloadFall 2016
Norepinephrine (NE) is a key neuromodulator that controls the longevity of synaptic plasticity such as long term potentiation (LTP). Activation of beta-adrenergic receptors (β-ARs) is known to boost persistence of LTP in area CA1 of mouse hippocampal slices. Activity-induced weakening...
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Fall 2011
The ability of synapses to undergo lasting changes in synaptic strength is considered the primary cellular mechanism for associative memory formation in the mammalian brain. Synapses in the hippocampus, a brain structure required for new memory genesis, exhibit a remarkable capacity for...