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- 1Activation-induced cytidine deaminase
- 1Activation-induced deaminase
- 1Adaptive immunity
- 1Antigen presentation
- 1CRISPR
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Fall 2012
The recognition of virus infected cells by cytotoxic T lymphocytes is dependent on antigen presentation by MHC class I on the cell surface. Antigen presentation is critically dependent on the transporter associated with antigen processing (TAP), which facilitates the transport of peptides across...
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Fall 2021
Ducks, as the natural reservoir host of influenza A virus (IAV), do not exhibit the same detrimental symptoms when infected by IAV as other susceptible host species, such as chickens and humans. A dysregulated NLRP3 inflammasome response activated by IAV has been linked to severe host outcomes,...
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Fall 2020
Antigen-specific recognition and memory, the hallmarks of conventional mammalian adaptive immunity, are found in all jawed vertebrates along with all elements central to cognate adaptive immune responses (e.g. B-cells). During T-cell-dependent humoral immune responses in mammals, antigen-specific...
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Spring 2016
Ducks are the natural reservoir of influenza A virus. Normally, the virus replicates in their intestine and is passed in the feces, although highly pathogenic influenza A virus replicates in the lungs. Influenza infection in ducks is frequently asymptomatic. During infection with highly...
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Stable knock-in of duck RIG-I into DF-1 chicken cells via CRISPR/Cas9 homology directed repair
DownloadFall 2020
Chickens and ducks differ in their susceptibility to avian influenza virus infection. Ducks are the primordial hosts and reservoir of avian influenza A viruses. Mallard ducks can asymptomatically harbour high-pathogenicity avian influenza (HPAI) and low-pathogenicity avian influenza (LPAI)....
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Transcriptional regulation of two immune genes: teleost activation-induced cytidine deaminase and duck major histocompatibility complex class I
DownloadFall 2015
Differential gene expression allows organisms to develop specialized cell types and promptly respond to foreign pathogens. I) Activation-induced cytidine deaminase (AID/Aicda) is expressed in B-cells to diversify the secondary repertoire and effector functions of antibodies during the processes...