Search
Skip to Search Results-
Spring 2021
Splicing is an essential step in the post-transcriptional modification of pre-mRNAs in eukaryotes. This process is catalyzed by the spliceosome, a multi-megadalton nuclear protein-RNA enzyme which excises non-coding sequence from RNA transcripts prior to translation. Deficient or improper...
-
Spring 2022
Eukaryotes feature a split gene structure in which pre-mRNAs are spliced into mature RNAs prior to the translation of proteins. The splicing process is catalyzed by a dynamic multi-subunit molecular machine known as the spliceosome that assembles in a stepwise fashion. An early complex formed in...
-
Spring 2010
More than 90% of human genes undergo a processing step called splicing, whereby non-coding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Roughly 50% of human genetic diseases correspond to aberrant splicing. Splicing is...
-
Fall 2015
Over 90% of eukaryotic genes are initially expressed as precursor-messenger RNAs (pre-mRNAs) that contain coding exon sequences interrupted by non-coding intron sequences. The introns are excised and exons are ligated together to form messenger RNA (mRNA) through a process called splicing....
-
Spring 2012
More than 90% of human genes undergo a processing step called splicing, whereby noncoding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Splicing involves two sequential transesterification reactions catalyzed by a large...