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In differentiating cells, genes are silenced or transcribed through changes in chromatin organization. Active chromatin is known as euchromatin and repressive chromatin is known as heterochromatin. These active or repressive states are initiated and maintained by modifying residues of the core...
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...