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Skip to Search Results- 16-Mercaptopurine
- 1Acute Lymphoblastic Leukemia
- 1Complex
- 1ENT1
- 1Equilibrative Nucleobase Transporter 1
- 1Membrane Transporters
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Function and Regulation of Equilibrative Nucleobase Transporter 1 in Acute Lymphoblastic Leukemia
DownloadFall 2024
Background: 6-Mercaptopurine (6-MP) is a purine nucleobase analog used for the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel disease, and other disorders. 6-MP is primarily used in ALL, the most common childhood cancer. Enzymes involved in 6-MP metabolism have been shown to...
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Spring 2024
6-Mercaptopurine (6-MP) maintenance therapy is the mainstay for various types of leukemia and inflammatory bowel disease (IBD). 6-MP is associated with numerous adverse effects including gastrointestinal intolerance, myelotoxicity and hepatotoxicity. This can lead to therapy discontinuation which...
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Spring 2016
Equilibrative nucleoside transporter 1 (ENT1) is an ubiquitously expressed membrane transporter in mammalian cells responsible for the transmembrane flux of endogenous nucleosides such as adenosine, as well as chemotherapeutic, anti-viral, and anti-parasitic nucleoside analogues. The present...