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Development of a Novel Piglet Model to Simulate the Physiology of a Child with Hypoplastic Left Heart Syndrome during the First Interstage for Investigating Changes in Tricuspid Valve as it Adapts to a High-pressure and High-volume Stress EnvironmentDownload
INTRODUCTION: Tricuspid valve (TV) failure develops in 25-35% of children with hypoplastic left heart syndrome (HLHS) and is a risk factor for morbidity and mortality. The mechanisms underlying TV failure in HLHS are not well understood. There is no effective medical therapy and current surgical...
Chronic kidney disease and end-stage renal disease (ESRD) are becoming increasingly prevalent in the world. The World Health Organization estimates that in 2015, 1.2 million people died from kidney failure, an increase of 32% from a decade ago. An estimated 2 million people worldwide are...
Ex Vivo Heart Perfusion (EVHP) preserves a donor heart’s natural beating function outside of the body. The purpose of this work was to study the influence of mock aorta properties on pump performance in a mechanical EVHP system. Previous work has shown potential benefits on pump workload by...