Search
Skip to Search Results- 1Bond, David JE
- 1Galenza, Anthony
- 1Gordon, Marilyn H
- 1Parsons, Brendon D
- 1Schindler, Anja
- 1Willms, Reegan J
-
Fall 2020
Interactions between diet, lifespan, metabolism, and immunity are complex but can have profound impact on human health. The Drosophila model is useful to study these interactions as many pathways and processes are highly conserved between flies and humans. In this thesis, I used the defined...
-
Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
-
Spring 2024
To maintain an effective barrier, intestinal epithelial progenitor cells must divide at a rate that matches the loss of dead and dying cells. Epithelial damage during most enteric infection accelerates cell proliferation and tissue repair via multiple stress responses. However, infection with the...
-
Fall 2023
The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial...
-
Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
-
Spring 2013
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...
-
Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...