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Spring 2010
Anion Exchanger 1, AE1, is a membrane glycoprotein that functions as a dimer in the red blood cells (RBC) as well the kidney. It functions to exchange Cl- for HCO3- in an electroneutral manner, with the RBC AE1 having an additional function in maintaining its biconcave shape. Mutations in AE1...
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Deciphering the Roles of 2 Intercalated Cell Proteins in Acid-Base and Ion Homeostasis: SLC26A7 and Claudin-4
DownloadFall 2022
Few of the many crucial physiological functions are maintaining acid/base balance and electrolyte homeostasis. The last segment of the nephron, collecting duct, fine tunes these functions by secreting acids and reabsorbing bicarbonate through the specialized type-A intercalated cells (Type-A IC)....
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Fall 2012
The kidney anion exchanger 1 (kAE1) is crucial in the regulation of physiological pH by facilitating Cl-/HCO3- exchange. Inability to do so results in distal renal tubular acidosis (dRTA), which is more often due to mutations leading to mis-localization of kAE1, rather than complete abolishment...
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The Physiological Role of Kidney Anion Exchanger 1 Protein Interaction with Adaptor Protein 1 A and B
DownloadSpring 2015
Distal Renal Tubular Acidosis (dRTA) is a disease characterized by metabolic acidosis, an inability to acidify urine, development of kidney stones and renal failure if untreated. dRTA patients can carry a mutation in the SLC4A1 gene encoding the kidney anion exchanger 1 (kAE1), a Cl-/HCO3-...