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Skip to Search Results- 1AE3
- 1Bicarbonate transport
- 1Bicarbonate transporters, carbonic anhydrase
- 1Carbonic anhydrase
- 1Chloride/bicarbonate exchanger AE1
- 1Endothelial corneal dystrophies
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Spring 2012
Cardiac hypertrophy is maladaptive remodeling of the myocardium that often progresses to heart failure. The hypertrophic transport metabolon consists of membrane transporters implicated in hypertrophy, and substrates for these transporters are provided by the catalytic action of carbonic...
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Identification of Protein-Protein Interactors of the Corneal Dystrophy-Causing Protein, SLC4A11
DownloadSpring 2022
Endothelial corneal dystrophies are eye diseases characterized by dysfunction of the innermost layer of the cornea, resulting in disruption of the regulation and homeostasis of corneal deturgescence and, ultimately, impaired visual acuity. Gene mutations are responsible for many corneal...
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Fall 2020
AE1 mediates electroneutral Cl-/HCO3- exchange in red blood cells and kidney. The X-ray crystal structure of AE1 at 3.5 Å resolution provided the first human SLC4 protein structure at resolution sufficient to gain mechanistic insights, to AE1 specifically and to SLC4 family members by extension....
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Spring 2014
NHE1, whose activity and expression are elevated in cardiac hypertrophy, requires an acidifying pathway provided by AE3-mediated Cl-/HCO3- exchange to sustain its activity. Carbonic anhydrase II (CAII) interacts with NHE1 and AE3 to induce hypertrophy but the role of AE3 in hypertrophy is poorly...