This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Improving chemotherapeutic regimens by mitigating hearing loss as a limiting side-effect and examining transition metal ions as a ligand for zebrafish Tlr4
DownloadFall 2023
Cancer is often a debilitating disease associated with the uncontrolled growth of cells within an organism. We have made significant strides over the past few decades in treating many cancers, unfortunately, many of these treatments have unfavourable side effects. Cisplatin is a revolutionary...
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Investigating the Functional Consequences of the Interaction Between Engineered Ubiquitin Variants and the Salmonella Novel E3 Ligase SspH1
DownloadFall 2024
During infection some pathogenic gram-negative bacteria, such as Salmonella, manipulate the host ubiquitination system through the delivery of secreted effectors known as novel E3 ubiquitin ligases (NELs). Despite the presence of NELs amongst these well-studied bacterial species, their unique...
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Investigating the functions and interactions of Salmonella effector SspH2 with intracellular innate immune receptors
DownloadFall 2021
As part of its pathogenesis, Salmonella enterica serovar typhimurium delivers effector proteins into host cells. One such effector is SspH2, a member of the novel E3 ubiquitin ligase (NEL) family, which has been reported to interact with, and enhance, NOD1 pro-inflammatory signaling. It is still...