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Spring 2020
Activation of α5 GABAA receptors located on nodes of primary afferents have been found to produce a long lasting tonic primary afferent depolarization in the spinal cord (tonic PAD). In particular, C fibres have been found to be especially effective in eliciting this tonic PAD. Here by activating...
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Fall 2010
Brainstem derived serotonin (5-HT) normally facilitates spinal motoneuron excitability and inhibits sensory afferent transmission and associated spinal reflexes. Because the 5-HT innervation of the spinal cord is almost exclusively derived from brainstem neurons, spinal cord injury leads to an...
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