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A role for the nuclear pore complex protein Nup170p in defining chromatin structure and regulating gene expression
DownloadSpring 2012
The spatial organization of chromosomal loci within the nucleus can have a significant influence on transcriptional activity. Transcriptionally active genes are generally positioned within the nuclear interior. By contrast, the positioning of genes at the nuclear periphery is often correlated...
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A role for the nuclear transport machinery in supporting positive-strand RNA virus infection and in regulating innate immune responses
DownloadSpring 2015
In eukaryotic cells, the genetic material is encapsulated in a double lipid membrane layer to form the nuclear compartment. This double membrane layer, termed the nuclear envelope, is fenestrated by pores, which are occupied by proteinaceous gateway structures termed nuclear pore complexes...
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Spring 2018
Astronomy was a culturally prominent practice during the nineteenth century in Britain. In this thesis I examine the development of astronomy in one area, Wales. Astronomy became an important subject in the lecturing industry that emerged during the century as lecturers promoted astronomical...