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Spring 2017
ADP-ribosylation factors (Arfs) play a central role in the regulation of vesicular trafficking through the Golgi. Arfs are activated on cis-Golgi membranes exclusively by the guanine nucleotide exchange factor (GEF) Golgi-specific BFA resistance factor 1 (GBF1), upon recruitment from cytosol....
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A novel group of zebrafish Class II ADP-ribosylation factors and their potential role in photoreceptor development
DownloadFall 2013
In this study we identified an unknown set of Class II Arf isoforms in zebrafish. Bioinformatics analyses grouped these paralogues into three distinct clades. Using antisense morpholino gene knockdown, we tested the effect of loss of each zebrafish Class II Arf on early development and...
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Fall 2010
In this thesis, I characterized the association of Arf4•GDP with ER-Golgi intermediate compartment membranes. We confirmed that GDP-arrested Arf4 mutants associated with membranes irrespective of nature of tag or mutation. Recruitment appeared specific since loss of N-terminal myristoylation...