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Identification of CECR2-containing chromatin-remodeling complexes and their Chromatin-binding sites in mice
DownloadSpring 2017
Eukaryotic nuclear DNA is packaged into chromatin, a complex nucleoprotein structure. This has functional consequences by controlling the accessibility of DNA to binding factors responsible for many important cellular processes such as transcription, DNA replication and DNA repair. ATP-dependent...
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Fall 2015
Neurulation, the early developmental process that forms the rudiment of the brain and spinal cord, relies upon the intricate interplay of hundreds of genes in multiple genetic pathways within the appropriate environmental conditions. Neural tube defects (NTDs), common congenital birth defects in...
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Spring 2020
In both mice and humans, defects in spermatogenesis, oogenesis, and pregnancy can all affect fertility. Spermatogenesis requires the constant renewal of spermatogonial stem cells, completion of meiosis, and an intricate remodeling process to form functional spermatozoa. Oogenesis similarly...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...