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Fall 2012
The recognition of virus infected cells by cytotoxic T lymphocytes is dependent on antigen presentation by MHC class I on the cell surface. Antigen presentation is critically dependent on the transporter associated with antigen processing (TAP), which facilitates the transport of peptides across...
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Fall 2021
Ducks, as the natural reservoir host of influenza A virus (IAV), do not exhibit the same detrimental symptoms when infected by IAV as other susceptible host species, such as chickens and humans. A dysregulated NLRP3 inflammasome response activated by IAV has been linked to severe host outcomes,...
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Fall 2022
Ducks are the natural host and reservoir of influenza A virus (IAV). It is currently unknown how ducks can both tolerate and restrict IAV replication. It is likely that ducks have evolved unique transcriptional responses to IAV infection to restrict virus while limiting damage from inflammation,...
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Spring 2016
Ducks are the natural reservoir of influenza A virus. Normally, the virus replicates in their intestine and is passed in the feces, although highly pathogenic influenza A virus replicates in the lungs. Influenza infection in ducks is frequently asymptomatic. During infection with highly...
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Stable knock-in of duck RIG-I into DF-1 chicken cells via CRISPR/Cas9 homology directed repair
DownloadFall 2020
Chickens and ducks differ in their susceptibility to avian influenza virus infection. Ducks are the primordial hosts and reservoir of avian influenza A viruses. Mallard ducks can asymptomatically harbour high-pathogenicity avian influenza (HPAI) and low-pathogenicity avian influenza (LPAI)....
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Transcriptional regulation of two immune genes: teleost activation-induced cytidine deaminase and duck major histocompatibility complex class I
DownloadFall 2015
Differential gene expression allows organisms to develop specialized cell types and promptly respond to foreign pathogens. I) Activation-induced cytidine deaminase (AID/Aicda) is expressed in B-cells to diversify the secondary repertoire and effector functions of antibodies during the processes...