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- 1Bicarbonate buffer
- 1Bioavailability
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- 1Biphasic dissolution
- 1Chylomicrons
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Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
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Evaluation of performance testing and computer simulations for Quality by Design approaches of oral dosage forms
DownloadSpring 2011
Performance testing and computer simulations have promising applications in Quality by Design approaches. The objectives of these studies were to investigate the performance of the disintegration test using different setups in addition to comparing the performance of the disintegration test with...
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Novel Biopharmaceutical Development Investigations Towards Drug and Formulation Performance Optimization
DownloadFall 2021
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of...