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2003

Monzavi, H., Willard, L., Zhang, H., Boyko, R.F., Ranjan, A., Wishart, D.S., Sykes, B.D.

VADAR (Volume Area Dihedral Angle Reporter) is a comprehensive web server for quantitative protein structure evaluation. It accepts Protein Data Bank (PDB) formatted files or PDB accession numbers as input and calculates, identifies, graphs, reports and/ or evaluates a large number (>30) of key

structural parameters both for individual residues and for the entire protein. These include excluded volume, accessible surface area, backbone and side chain dihedral angles, secondary structure, hydrogen bonding partners, hydrogen bond energies, steric quality, solvation free energy as well as local and

2005

Owttrim, George W., Chamot, Danuta, Kujat-Choy, Sonya L., Colvin, Kimberley R.

Rearrangement of RNA secondary structure is crucial for numerous biological processes. RNA helicases participate in these rearrangements through the unwinding of duplex RNA. We report here that the redox-regulated cyanobacterial RNA helicase, CrhR, is a bona fide RNA helicase possessing both RNA

characteristic of RNA helicases. Biochemically, CrhR resembles RecA and related proteins that catalyze strand exchange and branch migration on DNA substrates, a characteristic that is reflected in the recently reported structural similarities between these proteins. The data indicate the potential for CrhR to

2015-09-28

Ramya Varadarajan

maintaining pre-meiotic oocyte arrest in many animal models. Earlier reports from the Campbell lab, however, have shown that loss of Myt1 activity affected multiple aspects of Drosophila spermatogenesis resulting in male sterility. The conserved meiotic checkpoint function of Myt1 was hypothesized to account

overall coordination of G2/MI transition. Instead, the phenotypic analysis of myt1 mutants indicated that Myt1 activity is required for structural integrity of a germline specific membranous cytoskeletal organelle called the fusome (or intercellular bridges). I found that inhibition of Cyclin A-Cdk1