Search
Skip to Search Results- 1Burkat, Michael
- 1Campbell, Stephen J.
- 1Hodge, Curtis D
- 1Islam, Md Touhidul
- 1Kim, Hyeong Jin
- 1Kulepa, Ayodeji N
-
Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM
DownloadFall 2014
The conjugative transfer of bacterial F plasmids relies on TraM, a plasmid-encoded protein that recognizes multiple DNA sites to recruit the plasmid to the conjugative pore. In spite of the high degree of amino acid sequence conservation between TraM proteins, many of these proteins have markedly...
-
Fall 2015
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
-
Development of Systems for Expression, Purification, and CK2-Mediated Phosphorylation of the Histone Oligomers
DownloadFall 2018
It is of extreme importance to investigate the DNA repair pathways that will lead to a better understanding to develop cancer treatments since the primary cause of cancer is the inability of the cell to restore the damaged DNA. Upon DNA damage, the histone tails of the nucleosomes near the DNA...
-
Fall 2012
In response to genomic stress resulting from external and endogenous insults, the cell has acquired a set of complicated pathways that deal with the damage, which are collectively referred to as the DNA damage response (DDR). In order to repair double strand DNA breaks that may have occurred in...
-
Fall 2014
Multidrug resistant bacteria pose a threat to human health and economic burden for the healthcare system. Transmission of antibiotic resistance genes can occur by the conjugative transfer of the F plasmid between bacteria. The transferosome forms a channel linking the two cells together, while...
-
Spring 2018
The BRCT domain family is a group of proteins that is primarily involved in the regulation of DNA replication, cell cycle checkpoint activation, DNA damage repair, and many other DNA damage responses (DDR). Mutations in BRCT proteins often result in genomic instability, one of the leading sources...
-
Fall 2011
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
-
Fall 2013
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) is a SWI2/SNF2 chromatin remodeler. It reanneals stalled replication forks to maintain genome integrity. It contains HARP domains that are necessary for the annealing activity. This thesis...
-
Structural insight of transcriptional terminator recognition by ProQ/FinO domain RNA chaperones
DownloadFall 2022
The ProQ/FinO family is an emerging group of RNA binding proteins that are critical for sRNA-mediated gene regulation in proteobacteria. The ProQ/FinO domain of these proteins recognizes a transcriptional terminator, hairpin-tail structure, to regulate gene expression. The important role of the...
-
Fall 2017
The Apoptotic Stimulating Proteins of p53 (ASPPs) are key regulators of the human tumour suppressor transcription factor, p53. These regulators either activate (ASPP1 and ASPP2) or inhibit (iASPP) p53’s function in response to DNA damage. iASPP is overexpressed and attributed to poor survival in...