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Skip to Search Results- 2NLRP3 inflammasome
- 112,13-DiHOME
- 1Cardiac inflammation
- 1Cyclic AMP
- 1Cytochrome P450 epoxygenase
- 1Dihydroxyeicosatrienoic acids (DHETs)
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Effects of Genetic Deletion of Soluble Epoxide Hydrolase on Cardiac Function and Inflammation in Acute Lipopolysaccharide Injury
DownloadSpring 2022
Acute inflammatory syndromes, such as endotoxemia, elicit detrimental multi-organ responses resulting in cardiac dysfunction often leading to death. Emerging evidence suggests epoxylipids can exert cardioprotective effects by modulating the NOD-like receptor family pyrin domain containing 3...
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Role of cytochrome P450 (CYP) metabolites of arachidonic acid in the regulation of cAMP in HEK293 cells
DownloadFall 2011
Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). EETs are known to modulate a number of vascular and renal functions but the exact signaling...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...