This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results- 1Doxorubicin-Induced Cardiotoxicity
- 1Endoplasmic/Sarcoplasmic Reticulum
- 1Inflammasomes
- 1JPH-2
- 1Junctophillin-2
- 1MMP-2
-
Novel Roles of Matrix Metalloproteinase-2 in Mitochondrial and Endoplasmic/Sarcoplasmic Reticulum Dysregulation
DownloadFall 2024
Matrix metalloproteinase-2 (MMP-2) is a ubiquitous multifunctional protease that cleaves both extracellular and intracellular proteins. MMP-2 is synthesized as an inactive zymogen. It is rapidly activated inside the cell in response to oxidative stress during different cardiac pathologies such as...
-
Role of matrix metalloproteinase-2 in sarcoplasmic reticulum dysfunction during myocardial ischemia-reperfusion injury
DownloadSpring 2019
Matrix metalloproteinase-2 (MMP-2) is an intra- and extra-cellular protease which is activated during myocardial ischemia-reperfusion (IR) injury by reactive oxygen and nitrogen species, namely peroxynitrite. Upon its activation, MMP-2 impairs cardiac contractility by cleaving sarcomeric and...