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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Studying Systemic Metabolic Remodeling and Abnormal Mitochondrial Signaling in Primary Biliary Cholangitis
DownloadFall 2024
Primary biliary cholangitis (PBC) is linked with the production of anti-mitochondrial antibodies (AMA) targeting pyruvate dehydrogenase complex-E2 subunit (PDC-E2). Cholangiocytes from PBC patients express increased PDC-E2, which is thought to result in loss of tolerance to mitochondrial...